Stratification / Clinical classification

Single system LCH (SS-LCH)

One organ/system involved (uni- or multifocal):

  • Bone: unifocal (single bone) or multifocal (> 1 bone)
  • Skin
  • Lymph node
  • Hypothalamic-pituitary / Central nervous system
  • Lungs (primary pulmonary LCH)
  • Other (e.g. thyroid, gut)

Multisystem LCH (MS-LCH)

Two or more organs/systems involved:

  • With involvement of “risk organs” (hematopoietic system, spleen, and/or liver, tumorous CNS)
  • Without involvement of “risk organs”